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. 2020 Mar 4;12(3):587. doi: 10.3390/cancers12030587

Figure 8.

Figure 8

TLD1433 treatment by IV administration in the zebrafish ectopic and orthotopic CM model. (A) Schedule of tumour injection and TLD1433 administration in zebrafish embryos. Relative tumour burden was calculated as described in Figure 7. (B) CRMM1 tumour burden in the ectopic model (n ≈ 30). (C) CRMM1 tumour burden in the orthotopic model (n ≈ 15). (D) CRMM2 tumour burden in the ectopic model (n ≈ 30). (E) CRMM2 tumour burden in the orthotopic model (n ≈ 15). Results are presented as means ± SD from three independent experiments. Representative images show CM tumour burden in the head and tail regions in ectopic model and localised tumours in the orthotopic model.