Table 2.
A Cox proportional hazards analysis of plasma free and total IAA levels (stratified by the median) for predicting (A) all-cause mortality and (B) cardiovascular events in the non-transplanted CKD cohort (n = 140).
| A | ||||
|---|---|---|---|---|
| Models | Free IAA | Total IAA | ||
| HR [95%CI] | p | HR [95%CI] | p | |
| Unadjusted | 3.1 [1.6–6.2] | 0.001 | 2.7 [1.4–5.2] | 0.003 |
| +age | 3.4 [1.7–6.8] | <0.0001 | 2.9 [1.5–5.5] | 0.001 |
| +age + CRP + hemoglobin | 2.3 [1.1–4.9] | 0.027 | 2.9 [1.5–5.5] | 0.002 |
| +age + CRP + albumin | 2.3 [1.1–4.9] | 0.027 | 2.5 [1.3–4.7] | 0.007 |
| +age+ CRP + dialysis | 2.5 [1.2–5.1] | 0.017 | 2.0 [0.9–4.1] | 0.070 |
| B | ||||
| Models | Free IAA | Total IAA | ||
| HR [95%CI] | p | HR [95%CI] | p | |
| Unadjusted | 2.3 [1.3–4.3] | 0.006 | 1.3 [0.7–2.3] | 0.378 |
| +age | 2.5 [1.4–4.7] | 0.002 | 1.3 [0.8–2.4] | 0.322 |
| +age + CRP + hemoglobin | 2.5 [1.3–4.6] | 0.031 | 1.3 [0.7–2.3] | 0.298 |
| +age + CRP + albumin | 2.1 [1.1–3.9] | 0.016 | 1.1 [0.6–2.1] | 0.612 |
| +age + CRP+ history of cardiovascular disease | 2.5 [1.3–4.6] | 0.004 | 1.3 [0.7–2.3] | 0.365 |
| +age + CRP +dialysis | 2.5 [1.3–4.8] | 0.004 | 1.1 [0.6–2.2] | 0.639 |
HR = hazard ratio summarizing the effect of above- and below-median levels of IAA (i.e., free IAA > 0.0285 mg/dl vs. with ≤0.0285 mg/dl, and total IAA > 0.101 mg/dl vs. ≤0.101 mg/dl) on the overall mortality risk in an unadjusted model and in models adjusted for the covariates mentioned.