Figure 1.

Eukaryotic thiol chemistry and the generation of thiol-based signaling molecules. Orange highlight shows product signaling molecules. AKR1A1—aldoketoreductase family 1 member 1A, CAT—cysteine aspartate aminotransferase, CBS—cystathionine b-synthase, CSE—cystathionine gamma lyase, CDO—cysteine deoxygenase, CoA—Coenzyme A, C-SNO—S-nitrosocysteine, GSNO—S-nitrosoglutathione, GSNOR—S-nitrosoglutathione reductase, GS—glutathione synthase, GCS—glutamylcysteine synthase, MAT—methionine adenosyltransferase; SAM- S-adenosyl methionine; 3MST—3 mercaptopuruvate sulfur transferase, PTA—pantetheinase, SNO-CoA—S-nitroso-Coenzyme A, γGT—γ-glutamyl transpeptidase.