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. 2020 Mar 21;21(6):2176. doi: 10.3390/ijms21062176

Figure 1.

Figure 1

Effect of chronic cerebral hypoperfusion (CCH) on mice at 3 months after the bilateral common carotid artery occlusion (BCCAO) and sham surgery. (A) Cerebral blood flow (CBF) reduced to 50–70% from the baseline in BCCAO mice; (B) CCH did not alter motor coordination, which was observed as no difference in the rotarod and beam-walking test; (C) Novel object recognition (NOR) test showed that BCCAO mice had memory decline compared with sham mice after CCH induction; (D) CCH induced hippocampal atrophy in BCCAO mice (the area of hippocampus is shown by a red circle). n = 6 for each group. Data are presented as the mean + standard deviation; * p < 0.05 by unpaired t-test (hippocampal volume); **** p < 0.0001 by two-way analysis of variance followed by Sidak’s multiple comparison test (CBF ratio and NOR). Sham R: right brain area of sham mice, sham L: left brain area of sham mice, BCCAO R: right brain area of BCCAO mice, BCCAO L: left brain area of BCCAO mice.