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. 2020 Mar 21;21(6):2176. doi: 10.3390/ijms21062176

Figure 3.

Figure 3

Increased high-mobility group box protein 1 (HMGB1) and its proinflammatory cytokines (tumor necrosis factor-alpha [TNF-α] and interleukin [IL]-1β) in the cortex and hippocampus at 3 months after chronic cerebral hypoperfusion (CCH). (A) Western blot results of HMGB1 in the cortex and hippocampus. (B) Quantification results of HMGB1 relative protein in the cortex and hippocampus. (C) Immunostaining of HMGB1, TNF-α, and IL-1β in the cortex. (D) Quantification data of immunostaining image. n = 6 for each group. Data are presented as the mean + standard deviation; *p < 0.05; **p < 0.01 with unpaired t-test; scale bar = 50 μm.