Markers of mitochondrial volume and the antioxidant response element signaling. mRNA expression of sirtuin 1 (SIRT1), sirtuin 3 (SIRT3), peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α), nuclear respiratory factor-1 (NRF1), nuclear factor erythroid-2-related factor-2 (NRF2), NAD(P)H quinone dehydrogenase-1 (NQO1), 8-oxoguanine DNA glycosylase (OGG-1), and heme oxygenase-1 (HO-1). Values are represented as means ± SEM. * significantly different versus all groups (p < 0.05). # significantly different versus Saline-Saline (p < 0.05). ^ significantly different versus Saline-DOX (p < 0.05).