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Successive steps in paediatric bone tumour progression. Hypothetical implication of the YAP signaling pathway. YAP (yes-associated transcription factor coactivator) plays a major role at various crucial steps during tumor progression. In pediatric bone tumors, the Hippo signaling pathway may be involved in primary tumor growth, tumor angiogenesis, epithelial-mesenchymal transition, intravasation, extravasation, cell survival, and metastatic dissemination.
