Figure 7.

Aggregation kinetics of $\alpha$-synuclein at pH 4 in a non-binding surface plate under quiescent conditions in the absence of glass beads. The fibril formation was monitored in the presence and absence of EGCG or EGCG_ox and in wells that were pre-treated with EGCG-solutions (A) and the corresponding concentration measurement by Fluidity One after 160 h (B) with AFM height images (D) of the aggregation products of $\alpha$-synuclein (black frame) in the presence of EGCG_ox (1:1) (purple frame) and (1:5) (magenta frame), in the pre-treated wells with EGCG_ox (1:1) (light purple frame) and (1:5) (light magenta frame), and the overview of the three replicates per condition (C). The image scale is 5 × 5 μM. The color range represents the height from −3 to 12 nm.