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. 2020 Mar 11;21(6):1910. doi: 10.3390/ijms21061910

Figure 4.

Figure 4

NR2F2 binds to mother regions of ERα super-enhancers (SE) in MCF-7 breast cancer cells. (A) IGV screenshot shows that NR2F2 and ERα binding sites marked the mother and daughter regions of ERα SE with ERα bound chromatin interactions at WWC1 gene. (B) Box plots show the ERα and NR2F2 binding intensities on mother and daughter regions of ERα SE. Mann-Whitney test, **** significant at p < 0.0001. (C) Box plots show the ERα and NR2F2 binding intensities on anchor regions of ERα bound chromatin interactions based on number of interactions. Mann-Whitney test, **** significant at p < 0.0001. (D) Pie charts represent the percentage of mother (left) or daughter (right) regions of ERα SE overlapping with NR2F2 binding sites associated to ERα bound chromatin interactions.