Table 4.
The comparison of the colon cancer incidence densities between gallbladder stones patients with and without cholecystectomy, stratified by sex, location of cancer, and follow-up duration.
| Outcome | Cholecystectomy | Crude HR (95% CI) |
Adjusted HR § (95% CI) |
|||
|---|---|---|---|---|---|---|
| Yes | No | |||||
| Event | Rate # | Event | Rate # | |||
| Follow-Up Period ≤ 6 Months | ||||||
| All | ||||||
| Proximal colon cancer | 90 | 2.21 | 9 | 0.22 | 10.1 (5.09, 20.0) *** | 10.4 (5.23, 25.6) *** |
| Distal colon cancer | 52 | 1.27 | 7 | 0.17 | 7.51 (3.41, 16.5) *** | 7.70 (3.50, 17.0) *** |
| Rectal cancer | 102 | 2.50 | 13 | 0.31 | 7.93 (4.45, 14.1) *** | 8.06 (4.53, 14.4) *** |
| Female | ||||||
| Proximal colon cancer | 49 | 2.61 | 4 | 0.21 | 12.4 (4.48, 34.4) *** | 13.0 (4.69, 36.0) *** |
| Distal colon cancer | 22 | 1.17 | 3 | 0.16 | 7.43 (2.23, 24.8) *** | 7.73 (2.31, 25.8) *** |
| Rectal cancer | 43 | 2.29 | 2 | 0.10 | 21.8 (5.28, 89.9) *** | 22.5 (5.46, 93.0) *** |
| Male | ||||||
| Proximal colon cancer | 44 | 2.00 | 9 | 0.40 | 4.94 (2.41, 10.1) *** | 4.99 (2.44, 10.2) *** |
| Distal colon cancer | 37 | 1.68 | 27 | 1.20 | 1.40 (0.85, 2.29) | 1.42 (0.86, 2.33) |
| Rectal cancer | 81 | 3.68 | 42 | 1.87 | 1.96 (1.35, 2.85) *** | 2.00 (1.38, 2.91) *** |
| Follow-Up Period > 6 Months | ||||||
| All | ||||||
| Proximal colon cancer | 70 | 0.17 | 121 | 0.23 | 0.77 (0.57, 1.03) | 0.72 (0.54, 0.97) * |
| Distal colon cancer | 93 | 0.22 | 173 | 0.33 | 0.70 (0.55, 0.90) ** | 0.65 (0.51, 0.84) *** |
| Rectal cancer | 149 | 0.35 | 289 | 0.55 | 0.66 (0.54, 0.81) *** | 0.63 (0.51, 0.77) *** |
| Female | ||||||
| Proximal colon cancer | 35 | 0.17 | 59 | 0.22 | 0.82 (0.54, 1.24) | 0.76 (0.50, 1.15) |
| Distal colon cancer | 32 | 0.16 | 62 | 0.24 | 0.70 (0.46, 1.08) | 0.66 (0.43, 1.02) |
| Rectal cancer | 56 | 0.28 | 116 | 0.44 | 0.67 (0.48, 0.92) * | 0.64 (0.46, 0.88) ** |
| Male | ||||||
| Proximal colon cancer | 32 | 0.14 | 58 | 0.22 | 0.71 (0.46, 1.10) | 0.68 (0.44, 1.04) |
| Distal colon cancer | 54 | 0.24 | 88 | 0.33 | 0.79 (0.56, 1.11) | 0.73 (0.52, 1.03) |
| Rectal cancer | 71 | 0.32 | 142 | 0.53 | 0.63 (0.47, 0.84) ** | 0.59 (0.44, 0.79) *** |
PY, person-years; Rate #, incidence rate per 1000 person-years. Crude HR, relative hazard ratio. Only those found to be significant in the univariable analysis were further examined in the multivariable analysis. Adjusted HR § multivariable analysis including age, gender, and comorbidities. * p < 0.05, ** p < 0.01, *** p < 0.001.