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. 2020 Mar 24;21(6):2253. doi: 10.3390/ijms21062253

Table 1.

Latest insights in cancer diagnosis using Surface-enhanced Raman spectroscopy, differing among label-free and SERS-encoded particles assays.

Author Target Cancer Sample Plasmonic Material LOD/Accuracy Year Reference
Koo et al. T2:ERG 1, PCA3 2, KLK2 3 miRNA Prostate cancer Urine AgNPs 40 nm Area under curve 0.84 2018 [10]
Girish et al. Oral squamous cell carcinoma
Verrucous carcinoma
Leukoplakia		 Oral cancer Mouth cancer tissue TiO2 nanostructures covered with AgNPs 30 nm 97,24 % 2019 [32]
Carmicheal et al. Exosome from CD18/HPAF, HPDE 4 and MiaPaca exosomes Pancreatic cancer Serum AuNPs 10 nm onto Ti/Au 40 nm/100 nm slide 87%−90% 2019 [33]
Lin et al. ctDNA Nasopharyngeal cancer Blood AgNPs 35 nm 82.9 % 2019 [34]
Bai et al. AFP 5,CEA 6,FER 7 proteins Liver cancer Serum AuNPs 50 nm 0.15, 20, and 4 pg/mL 2019 [35]
Li et al. miRNA-107 Prostate cancer Urine Au NSs-Hollowed alloy nanocubes 10−15 M 2019 [36]
Lee et al. CTCs and EBV 8 DNA Nasopharyngeal carcinoma Blood Si nanowires/microscale pyramids coated with Ag Nps 10−13 M 2019 [37]
Zhang et al. KARS G12 mutation ctDNA Lung cancer Serum Ag films 1.2 × 10−16 M 2019 [38]
Lee et al. Exosomal
miR-21, miR222, miR-200c		 Breast cancer Serum Head-flocked gold nanopillar 10−7 M 2019 [39]
Li et al. ER 9, EGFR 10, PR 11 tumor cells Breast cancer Cancer cells and breast cancer tissue AuNPs 60 nm ---- 2019 [40]
Wang et al. Exosomal ErbB2 protein Exosomal PSMA 12 protein Exosomal CEA 3 protein Breast cancer
Prostate cancer
Colorectal cancer		 Blood Au shell magnetic beads 32 exosomes/µL
73 exosomes/µL
203 exosomes/µL		 2018 [41]
Davis et al. CD47 and CA9 tumor proteins Bladder Cancer Bladder cancer tissue AuNPs Area under curve 0.94 2018 [42]
Zhu et al. miR-27a-3p, miR223, miR26a-5p
AFP		 Liver cancer Serum Ag films 10−15 M 2018 [43]

1 ERG: ETS-related gene. 2 PCA3: Prostate cancer antigen 3. 3 KLK2: Kallikrein 2. 4 HPDE: Human pancreatic ductal epithelial cells. 5 AFT: Alpha-Fetoprotein Tumor. 6 CEA: Carcinoembryonic antigen. 7 FER: Ferritin. 8 EBV: Epstein–Barr virus. 9 ER: Estrogen receptor. 10 EGFR: Epidermal growth factor receptor. 11 PR: Progesteron receptor. 12 PSMA: Prostate-specific membrane antigen.