Table 2.
Individual leukocyte telomere length (LTL)-associated single nucleotide polymorphisms (SNPs) and soft tissue sarcoma (STS) risk.
| SNP ID | Chr. | Position | Gene | Allele * | β * | EAF Case | EAF Control | OR ** (95% CI) | p Value |
|---|---|---|---|---|---|---|---|---|---|
| rs11125529 | 2 | 54475866 | ACYP2 | A/C | 0.065 | 0.131 | 0.129 | 1.01 (0.82–1.24) | 0.922 |
| rs6772228 | 3 | 58376019 | PXK | T/A | 0.041 | 0.942 | 0.948 | 0.9 (0.67–1.2) | 0.472 |
| rs10936599 | 3 | 169492101 | TERC | C/T | 0.1 | 0.756 | 0.737 | 1.11 (0.94–1.3) | 0.216 |
| rs7675998 | 4 | 164007820 | NAF1 | G/A | 0.048 | 0.8 | 0.766 | 1.21 (1.02–1.43) | 0.026 |
| rs2736100 | 5 | 1286516 | TERT | C/A | 0.085 | 0.487 | 0.48 | 1.02 (0.89–1.18) | 0.730 |
| rs9420907 | 10 | 105676465 | OBFC1 | C/A | 0.142 | 0.164 | 0.13 | 1.31 (1.08–1.59) | 0.007 |
| rs3027234 | 17 | 8136092 | CTC1 | C/T | 0.103 | 0.784 | 0.762 | 1.14 (0.96–1.34) | 0.127 |
| rs8105767 | 19 | 22215441 | ZNF208 | G/A | 0.064 | 0.317 | 0.283 | 1.18 (1.02–1.37) | 0.030 |
| rs412658 | 19 | 22359440 | ZNF676 | T/C | 0.086 | 0.382 | 0.344 | 1.18 (1.02–1.36) | 0.025 |
| rs6028466 | 20 | 38129002 | DHX35 | A/G | 0.058 | 0.066 | 0.059 | 1.13 (0.85–1.5) | 0.393 |
| rs755017 | 20 | 62421622 | ZBTB46 | G/A | 0.019 | 0.134 | 0.132 | 1.02 (0.84–1.25) | 0.832 |
* Alleles are short allele/long allele. Short alleles are used as the reference allele and long allele as effect allele. EAF: effect allele frequency; estimates of SNP–LTL association were from published genome-wide association studies (GWAS). ** Adjusted by age and gender.