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. 2020 Feb 28;12(3):558. doi: 10.3390/cancers12030558

Figure 6.

Figure 6

Schematic representation of genetic mechanisms of telomerase activation. (A) TERT gene amplification leading to an increase in TERT copy number at the 5p15.33 locus; (B) genomic rearrangement in TERT result in inter-chromosomal translocation; (C) Mutations at two hotspots in the TERT promoter, −124 and −146 bp from ATG start site create de novo binding sites for ETS transcription factors (red circles). Various transcriptional binding elements are represented in the core promoter region, E-box (green), ETS (red), and Sp1 (blue). Adapted from [12,97,145].