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. 2020 Mar 16;21(6):2008. doi: 10.3390/ijms21062008

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Dual role of NDP52 in Salmonella infection. Salmonella colonizes within Salmonella-containing vesicles (SCV) and replicates itself. After the vesicles burst, they are released into the cytoplasm and reproduce in large numbers. NDP52 identify and target Salmonella that are released into the cytoplasm through its UBZ domain and LC3c binding site (CLIR motif), and, independently, regulates autophagosome maturation through its LC3a, LC3b, or Gabarapl2 binding site (LIR-like motif) and its Myo6 interacting region (modified from [37]).