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The mechanism of NDP52 in CSFV infections. In the CSFV infection PK-15 cells, NDP52 protein co-localized with CSFV E2 protein in the cytoplasm. Inhibition of NDP52 reduces the binding of E2 protein and lysosomal marker molecule CD63. The inhibition of NDP52 promotes the activation of the NF-κB signaling pathway and promotes the release of cytokines such as IFNα, inhibiting CSFV replication (Arrow shape indicates next step, T shape indicates suppression).
