Table 1.

Brief summary on six important genes potentially involved in atherosclerosis development.

Name	Gene ID	Link to Atherosclerosis	Normal Function	Identification (Organism, Method)	Reference
ALOX5AP	241	Genetic variants are potentially contributed to the higher coronary heart disease risk	Part of leukotriene biosynthesis pathway	Human, haplotype association study	[22]
MEF2A	4205	MEF2A signaling pathway is involved in pathogenesis of familial CAD and MI	Myocyte-specific transcription factor	Human, linkage study	[17]
Alox5	11689	homozygote 5LO null mice develop smaller atherosclerotic lesions	Part of leukotriene biosynthesis pathway	Mouse, linkage study	[18]
Tnfsf4	22164	blocking the OX-40/OX40L interaction reduced atherogenesis	OX40 ligand	Mouse, linkage study	[19]
LTA	4049	Genetic variants are potentially contributed to the higher MI risk	Lymphocyte cytokine	Human, GWAS	[20]
PSMA6	5687	PSMA6 rs_1048990 polymorphism may contribute to MI susceptibility in type 2 diabetes	-	Human, GWAS	[23]

CAD: coronary artery disease; MI: myocardial infarction; GWAS: genome-wide association study.