Table 2.
Univariate analysis of clinical-pathological parameters for the prediction of cancer-specific survival, overall survival and loco-regional control.
| Criterion | Cancer–Specific Survival | Overall Survival | Loco-Regional Control | |||
|---|---|---|---|---|---|---|
| HR (95% CI) * | p-Value | HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
| Sex | ||||||
| Male | 1 | 1 | 1 | |||
| Female | 1.15 (0.78–1.70) | 0.469 | 0.93 (0.67–1.30) | 0.681 | 1.09 (0.76–1.57) | 0.636 |
| Age (continuous) | 1.01 (0.99–1.02) | 0.412 | 1.01 (0.996–1.02) | 0.191 | 1.01 (0.99–1.02) | 0.508 |
| BMI (continuous) | 0.93 (0.89–0.98) | 0.003 | 0.92 (0.88–0.96) | <0.001 | 0.94 (0.90–0.98) | 0.003 |
| Smoking status | ||||||
| Former/never | 1 | 1 | 1 | |||
| Current | 1.54 (1.05–2.25) | 0.028 | 1.62 (1.18–2.24) | 0.003 | 1.55 (1.08–2.21) | 0.016 |
| Alcohol abuse | ||||||
| Former/never | 1 | 1 | 1 | |||
| Current | 1.83 (1.29–2.59) | 0.001 | 2.04 (1.52–2.73) | <0.001 | 1.65 (1.19–2.29) | 0.003 |
| Tumor site | ||||||
| Oropharynx | 1 | 1 | 1 | |||
| Oral cavity | 1.82 (1.29–2.58) | 0.001 | 1.29 (0.96–1.72) | 0.092 | 1.90 (1.37–2.63) | <0.001 |
| Tumor grade | ||||||
| G 1/2 | 1 | 1 | 1 | |||
| G 3/4 | 1.04 (0.74–1.48) | 0.807 | 0.98 (0.73–1.31) | 0.889 | 0.89 (0.65–1.24) | 0.502 |
| Tumor stage | ||||||
| T 1/2 | 1 | 1 | 1 | |||
| T 3/4 | 2.24 (1.52–3.31) | <0.001 | 1.96 (1.43–2.68) | <0.001 | 2.80 (1.91–4.12) | <0.001 |
| Nodal involvement | ||||||
| No | 1 | 1 | 1 | |||
| Yes | 1.07 (0.68–1.70) | 0.774 | 1.02 (0.70–1.48) | 0.928 | 0.95 (0.63–1.43) | 0.787 |
| Surgery | ||||||
| No | 1 | 1 | 1 | |||
| Yes | 0.39 (0.27–0.56) | <0.001 | 0.43 (0.32–0.58) | <0.001 | 0.29 (0.21–0.42) | <0.001 |
| Induction chemotherapy | ||||||
| No | 1 | 1 | 1 | |||
| Yes | 1.52 (1.001–2.29) | 0.049 | 1.20 (0.83–1.73) | 0.341 | 1.61 (1.09–2.38) | 0.016 |
| Concomitant chemotherapy | ||||||
| No | ||||||
| Yes | 0.98 (0.68–1.40) | 0.898 | 1.05 (0.78–1.42) | 0.738 | 0.94 (0.68–1.31) | 0.721 |
| NLR (continuous) | 1.035 (0.975–1.098) | 0.257 | 1.047 (0.998–1.097) | 0.059 | 1.026 (0.969–1.086) | 0.38 |
| PLR (continuous) | 1.002 (1.000–1.003) | 0.038 | 1.001 (1.000–1.002) | 0.149 | 1.001 (1.000–1.003) | 0.186 |
| CRP (continuous) | 1.009 (1.005–1.013) | <0.001 | 1.008 (1.003–1.013) | 0.002 | 1.007 (1.003–1.012) | 0.002 |
| CRP | ||||||
| <5 | 1 | 1 | 1 | |||
| ≥5 | 1.95 (1.37–2.78) | <0.001 | 1.85 (1.38–2.47) | <0.001 | 1.73 (1.25–2.40) | 0.001 |
* Abbreviations: CI = confidence interval; HR = hazard ratio; BMI, body mass index; NLR, neutrophil/lymphocyte ratio; PLR, platelet/lymphocyte ratio; CRP, C-reactive protein.