Table 4.
Multivariate analysis of clinical-pathological parameters for the prediction of cancer-specific survival, overall survival and loco-regional control in patients treated with definitive (chemo-) radiotherapy.
| Criterion * | Cancer-Specific Survival | Overall Survival | Loco-Regional Control | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | P-Value | HR (95% CI) | p-Value | |
| BMI (continuous) | 0.96 (0.90–1.01) | 0.135 | 0.94 (0.90–0.99) | 0.015 | 0.97 (0.92–1.02) | 0.233 |
| Smoking status | ||||||
| Former/never | 1 | 1 | 1 | |||
| Current | 1.18 (0.66–2.09) | 0.574 | 0.94 (0.59–1.51) | 0.806 | 1.34 (0.80–2.23) | 0.269 |
| Alcohol abuse | ||||||
| Former/never | 1 | 1 | 1 | |||
| Current | 1.80 (1.10–2.92) | 0.019 | 1.79 (1.17–2.74) | 0.007 | 1.80 (1.16–2.80) | 0.009 |
| Primary site | ||||||
| Oropharynx | 1 | 1 | ||||
| Oral cavity | 1.65 (1.02–2.67) | 0.041 | - | - | 1.73 (1.1–2.73) | 0.018 |
| Concomitant chemotherapy | ||||||
| No | 1 | 1 | ||||
| Yes | - | - | 0.55 (0.35–0.87) | 0.01 | 0.59 (0.36–0.97) | 0.037 |
| CRP | ||||||
| <5 | 1 | 1 | 1 | |||
| ≥5 | 1.77 (1.09–2.89) | 0.022 | 1.75 (1.15–2.67) | 0.009 | 1.55 (1.01–2.39) | 0.046 |
* Multivariate Cox proportion analysis included parameters significantly associated with outcome in univariate analyses. Abbreviations: CI = confidence interval; HR = hazard ratio; BMI, body mass index; NLR, neutrophil/lymphocyte ratio; PLR, platelet/lymphocyte ratio; CRP, C-reactive protein.