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. 2020 Feb 27;12(3):545. doi: 10.3390/cancers12030545

Figure 1.

Figure 1

OR141 is an immunogenic cell death (ICD) inducer in mesothelioma cancer cells. Ab1 and Ab12 mesothelioma cells were treated with the indicated concentrations of OR141 for 1 h followed by exposure to white light LED for 1 h. (A) The molecular structure of OR141. (B) Cell death was measured using Annexin V and PI staining 18 h after OR141 photoactivation. (C) Extracellular (released) HSP90 and HMGB1 were detected by immunoblotting 18 h after OR141 photoactivation. (D) Calreticulin translocation in Ab1 cells 6 h after OR141 photoactivation was detected by flow cytometry. The data presented in this figure are representative of three different experiments.