Figure 4.

Radiation response of orthotopic RP-MOC1 tumors in immunocompetent mice. (A) Panel of images represents axial T2-weighted images of albino C57Bl/6 mice bearing orthotopic RP-MOC1 tumors during a 30-day monitoring period. Longitudinal MRI was performed once every 3–4 days during this period to assess tumor growth and response to radiation. Individual (B) and grouped (C) tumor growth curves based on MR-based tumor volume measurements obtained for animals in the control and radiation groups are shown. (D) Body weight measurements of animals in all three groups did not reveal any evidence of radiation toxicity. A gradual reduction in body weight associated with tumor growth was seen during the observation period.