Figure 1.

Schematic illustration of human proteins recruited in iron sequestration within the nutritional immunity (left), and Staphylococcus aureus effectors in iron retrieval (right). For protein representation, the following Protein Data Bank entries have been used: transferrin (1d3k), lactoferrin (1b0l), ferritin (1fha), hemopexin (1qhu), Hp 1-1 (extracted from 4wjg), IsdB^N1N2 (extracted from 5vmm), IsdH^N2N3 (extracted from 6tb2), FepB (3o72, illustration of the homolog Escherichia coli EfeB), and Hb/heme/iron (1a3n). Staphyloferrin A and B, and staphylopine have been modelled on the basis of Endicott et al. [46] and Deane [47] works, respectively. Proteins are divided into three groups based on the source of iron they exploit.