Figure 1.
Effects of selenium deficiency on selenoprotein expression in fetal liver at E18.5. Expression in male and female fetal livers, at E18.5, of; (A) thioredoxin reductase 1, (B) thioredoxin reductase 2, (C) glutathione peroxidase 1, (D) glutathione peroxidase 3, (E) deiodinase 1, (F) deiodinase 3, (G) selenoprotein F, (H) selenoprotein K, (I) selenoprotein M, (J) selenoprotein T, (K) selenoprotein S. (L) selenoprotein N and (M) selenoprotein P. Data are mean ± SEM and analysed by two-way ANOVA with treatment (Ptrt) and sex (Psex) as major factors. Pint represents the interaction between treatment and sex. Significance was determined as p < 0.05. If a major effect of treatment, sex or an interaction between treatment and sex was identified, then a Sidak posthoc test was performed. Significant differences between groups as detected by posthoc analysis are denoted by different letters where “A” is different from “B”, but not “AB”. The groups are Normal male, n = 6 (6 animals from 6 separate litters); Low male, n = 6 (from 6 separate litters); Normal female, n = 6 (from 6 separate litters); Low female, n = 6 (from 6 separate litters).
