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Schematic diagram of an alternative mechanism driving NRF2 activation upon PERK activation. In addition to the known NRF2 phosphorylation, activation of PERK triggers NRF2 transcription in an ATF4-dependent manner. During the protein synthesis recovery phase, subsequent generation of ROS induces the dissociation of the NRF2/KEAP1 complex, activation of the NRF2 antioxidant program and cell survival.
