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. 2020 Mar 10;12(3):641. doi: 10.3390/cancers12030641

Figure 1.

Figure 1

Role of stromal cells in the realization of premalignant microenvironment and HCC onset. HSCs (Hepatic Stellate Cells), TAMs (Tumor Associated Macrophages) and TANs (Tumor Associated Neutrophils) contribute respectively to induce liver fibrosis by matrix production, to promote tumor growth prompting the angiogenesis process and immune suppression leading to liver inflammation.