Aβplaque	β-amyloid plaques or senile plaques
AβPP	Amyloid-β precursor protein
Ach	Acetylcholine
AChE	Acetylcholinesterase
AChEI	Acetylcholinesterase inhibitors
AD	Alzheimer’s Disease
ADAM10	A disintegrin and metalloproteinase domain-containing protein 10
ADAM17	A disintegrin and metalloproteinasedomain-containing protein 17
(ADME)T	Absorption, distribution, metabolism, excretion, and toxicity prediction
AKT	Protein kinase B (PKB)
ApoE	Apolipoprotein E
APP IREs	APP internal ribosome entry site
ATF6	Activating transcription factor 6
ATP	Adenosine triphosphate
ATP5A	Allosteric α subunit of mATP synthase
BACE-1	β-secretase or beta-site amyloid precursor protein cleaving enzyme 1
Bax	Bcl-2-like protein 4
BBB	Blood–brainbarrier
BchE	Butrylcholinesterase
BcL-XL	B-cell lymphoma-extra large
Bcl-2	B-cell lymphoma 2
BDE	O-H proton dissociation enthalpy
BMAC	Boronatedmonocarbonyl analogues of curcumin
BNCT	Boron neutron capture therapy
Brain P53	Tumor proteinp53
CAAs	Cerebral amyloid angiopathies
Caspases	Cysteine-aspartic proteases
CAT	Catalase
CCCCV	Test set using LOO cross validation
CCCtr	The concordance correlationcoefficient of the training set
CHOP	C/EBP homologous protein
CNS	Central nervous system
CoMFA	Comparative molecular field analysis
CoMSIA	Comparative molecular similarity indices analysis
Cyt-c	Cytochrome complex
DART TOMFS	Direct analysis in real-time mass spectrometry
DAVID	Database for Annotation, Visualization and Integrated Discovery NIAID, NIH
DFT	Density functional theory
DIPEA	Diisopropylethylamine salt
DNA	Deoxyribonucleic acid
DPPH	2,2-Diphenyl-1-picrylhydrazyl radical scavenging
DTPA	Diethylenetriaminepentaacetic acid
EA	Calculated electronic affinity
elF2a	Eukaryotic translation initiation factor 2 alpha
ER	Endoplasmic reticulum
ERK1/2	Extracellular signal-regulated kinase
[18F]FDG	Fluorodeoxyglucose(18F)
F	Fisher ratio
F01[C-N]	Frequency of C-N at topological distance of 01, a 2D frequency fingerprints descriptor
FRSA	Free radical scavenging activities
GA-MLR	Genetic algorithme multilinear regression
GFP	pCMV6-htau40-green fluorescent protein
GIAO	Gauge-Independent Atomic Orbital
Glu339	Glutamate 339
Gly230	Glycine 230
GRP78	Glucose-regulated protein 78
GSH	Glutathione
GSK3β	Glycogen synthase kinase 3 beta
HEWL	Hen egg-white lysozyme
HQSAR	Hologram quantitative structure–activity relationship
HO-1	Heme oxygenase 1
i.c.v.	Intracerebroventricular
IL-6	Interleukin 6
IL-1β	Interleukin 1β
iNOS	Inducible NO synthase
IP	Ionization potential
IRE1	Inositol-requiring enzyme 1
Keap1	Kelch-like ECH-associated protein 1
KLVFFA peptide	Aβ-binding motif
LPS	Lipopolysaccharide
mATP synthase	Mitochondrial adenosine triphosphate synthase
MCI	Mild cognitive impairment
MD	Molecular dynamic
MDEC-44	Molecular distance edge between all quaternary carbons
MMPs	Matrix metallopeptidases
MRI	Magnetic resonance imaging
mRNA	Messenger RNA
MTDLs	Multitarget-directed Ligand
mTOR	Mammalian target of rapamycin
NEP	Neprilysin
Nex and Ntr	The numbers of samples in the training set and external set
NFTs	Neurofibrillary tangles
NIR(F)	Near infrared imaging (fluorescent)
NLs	Nanoliposomes
NMR	Nuclear magnetic resonance
2D NMR	Two-dimensional nuclear magnetic resonance
NO	Nitric oxide
Nrf2	Nuclear factor erythroid 2-related factor 2
NQO1	NAD(P)H:quinone acceptor oxidoreductase 1
OGD/R	Oxygen–glucose deprivation and re-oxygenation
ORAC-FL	Oxygen radical absorbance capacity assay using fluorescein
PEG	Polyethylene glycol
PERK	Protein kinase RNA like endoplasmic reticulum kinase
PET	Positron emission tomography
PI3K	Phosphoinositide 3-kinase
PKC	Protein kinase C
Presenilin	γ-secretase
PSD95	Postsynaptic density protein 95
PS1	Presenilin-1
PS2	Presenilin-2
p38 MAPK	p38 mitogen-activated protein kinase
QSAR	Quantitative structure–activity relationship
Q2	Cross-validated R2
Q2LOO	The square correlation coefficient for leave-one-out cross-validation
RDF090m	Radial distribution function 9.0/weighted by atomic masses, RDF descriptors
RNS	Reactive nitrogen species
ROS	Reactive oxygen species
R2	The square of correlation coefficient
R2adj	The adjusted determination coefficient
R2ex	Coefficient of determination
R2ncv	Non cross-validated correlation coefficient
R2pred	Predictive correlation coefficient
SAMP8	Senescence-accelerated mouse prone 8
sAPPα	Soluble amyloid precursor protein α
SAR	Structure–activity relationship
SEE	Standard errors of estimate
Skn-1	The nematode ortholog of Nrf2
SMD	Steered molecular dynamics
SOD	Superoxide dismutase
SOM	Site of metabolism
TBI	Traumatic brain injury
TC	Tetracycline
TERT	Telomerase reverse transcriptase
ThT assay	Thioflavin T fluorescence assay
TNF-α	Tumor necrosis factor –α
Trp63	Tryptophan 63
Tyr198	Tyrosine 198
WHIM	Weighted holistic invariant molecular
WK.eneg	Non-directional weighted holistic invariant molecular
XBP1	X-box-binding protein-1
5-LOX	5-lipoxygenase
8-OHG	8-hydroxyguanosine