Figure 5.

Summary. Effects of temperature, sequence, and time interval. A shorter time interval between ionizing radiation (IR) and hyperthermia (HT), a higher temperature of hyperthermia, and a higher dose of ionizing radiation were found to be of great importance in cell survival, by causing more residual DNA double strand breaks (DSBs) and higher levels of apoptosis. Either hyperthermia prior to ionizing radiation or hyperthermia after ionizing radiation did not matter on the number of DNA breaks, on the cell cycle distribution, levels of apoptosis, or on cell survival.