Table 4.
Tumor-to-organ ratios. Female Balb/c nu/nu mice with HER3-expressing BxPC-3 xenografts were injected with 2 µg [57Co]Co-(HE)3-ZHER3-X (X = NOTA, NODAGA, DOTA, DOTAGA).
| Tumor/Organ Ratios | NOTA | NODAGA | DOTA | DOTAGA | ||||
|---|---|---|---|---|---|---|---|---|
| 3 h | 24 h | 3 h | 24 h | 3 h | 24 h | 3 h | 24 h | |
| T/Blood | 1.5 ± 0.2 a,b,* | 3.4 ± 0.6 b | 4 ± 1a,d,e | 8 ± 3d | 8 ± 1 b,d,f,* | 18 ± 5 b,d,f | 1.8 ±0.3 e,f,* | 3.4 ± 0.5 f |
| T/Salivary gland | 1.8 ± 0.3 | 1.7 ± 0.3 | 1.7 ± 0.3 | 1.3 ± 0.7 d | 1.9 ± 0.2* | 2.9 ± 0.6 d | 1.5 ± 0.3 | 2.1 ± 0.9 |
| T/Lung | 1.6 ±0.3 * | 2.6 ± 0.4 | 1.6 ± 0.6 | 3 ± 1 | 1.6 ± 0.4* | 4.1 ± 0.9 e | 1.1 ±0.1* | 2.3 ± 0.4 e |
| T/Liver | 1.06 ± 0.31 c | 1.0 ± 0.2 b | 0.78 ± 0.09 e | 1.0 ± 0.3 | 0.74 ± 0.08 f,* | 1.6 ± 0.3 b,f | 0.44 ± 0.09 c,e,f | 0.50 ± 0.07 f |
| T/Spleen | 2.7 ± 0.3 a,b,* | 1.89 ±0.08 b | 6 ± 2 a,e | 4 ± 2 e | 6 ± 1 b,f | 6 ± 1 f | 1.2 ± 0.2 e,f | 1.2 ± 0.3 e,f |
| T/Stomach | 2.0 ± 0.2 * | 3.1 ± 0.8 | 1.7 ±0.4 | 2.1 ± 0.7 | 2 ± 0.2 * | 3.8 ± 0.9 | 1.6 ± 0.5 * | 2.5 ± 0.4 |
| T/Small intestine | 1.0 ± 0.2 b,* | 1.6 ± 0.2 | 0.6 ± 0.2 | 0.9 ± 0.4 | 0.60 ± 0.05 b,f | 1.3 ± 0.6 | 1.0 ± 0.1 e,f | 1.3 ± 0.2 |
| T/Muscle | 8 ± 2 a,b | 8 ± 1 b | 14 ± 4 a,e | 17 ± 7 d,e | 15 ± 1 b,f,* | 28 ± 4 b,d,f | 6 ± 1 e,f | 7 ± 2 e,f |
| T/Bone | 6 ± 3 | 4.3 ± 0.4 b | 10 ± 3 | 10 ±7 | 11 ± 2 f | 12 ± 3 e | 5 ± 3 f | 4 ± 1 e |
Data presented as the average ± SD of n = 4 animals per group. Significant difference (p < 0.05) between a: NOTA vs. NODAGA, b: NOTA vs. DOTA, c: NOTA vs. DOTAGA, d: NODAGA vs. DOTA, e: NODAGA vs. DOTAGA, f: DOTA vs. DOTAGA; * significant difference to 24 h.