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. 2020 Mar 23;21(6):2213. doi: 10.3390/ijms21062213

Figure 4.

Figure 4

Long-term, but not short-term CaN inhibition suppresses GLAST protein degradation. GLAST protein expression in primary cultures of hippocampal astrocytes from Ctr, Ctr treated with FK506 (200 nM) for 1 and 7 days and from astrocytes-specific CaN-KO mice. Where indicated, MG132 was added 3 h before lysis. Data are expressed as mean  ±  SD, 6 independent cultures were used for both Ctr and Ctr treated with FK506 for 7 days, 5 for CaN-KO, and 3 for Ctr treated with FK506 for 1 day. * p < 0.01; ** p < 0.01; *** p < 0.001, unpaired two-tailed Student’s t-test.