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. 2020 Mar 23;21(6):2228. doi: 10.3390/ijms21062228

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Chimeric miR-34aKO mice, compared to wild type (WT) are slightly more sensitive to Bleomycin-induced fibrosis. (A) Hematoxylin and eosin (H&E) staining at day 14 post-BLM vs. saline (SAL) (Upper panel), with graphical presentation of a semi-morphological index (SMI) (Lower panel), in WT and miR-34^KO murine lung tissue sections. (B) Masson-trichrome (Upper panel, blue) and (C) αSMA (brown) IHC and (B; Lower panel), graphical presentation of Sircoll-collagen assay. Bars () represent median score. Representative results from three independent experiments. Error bars represent mean ± SD; circles represent individual data points. * p ≤ 0.01–0.05.

Inline graphic — Chimeric miR-34aKO mice, compared to wild type (WT) are slightly more sensitive to Bleomycin-induced fibrosis. (A) Hematoxylin and eosin (H&E) staining at day 14 post-BLM vs. saline (SAL) (Upper panel), with graphical presentation of a semi-morphological index (SMI) (Lower panel), in WT and miR-34^KO murine lung tissue sections. (B) Masson-trichrome (Upper panel, blue) and (C) αSMA (brown) IHC and (B; Lower panel), graphical presentation of Sircoll-collagen assay. Bars () represent median score. Representative results from three independent experiments. Error bars represent mean ± SD; circles represent individual data points. * p ≤ 0.01–0.05.