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. 2020 Mar 13;12(3):667. doi: 10.3390/cancers12030667

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of bradykinin on the migration and invasion of human malignant glioblastoma cells. Human U87 MG glioblastoma cells were treated with 100 nM bradykinin for 24 h. A wound-healing assay was carried out to determine migration of U87 MG cells (A). Cell migration was quantified by analyzing the blank area (B). In parallel, invasion by U87 MG cells was further analyzed using a Matrigel-based invasion assay (C). Invading cells were counted and statistically analyzed (D). Human U87 MG cells were pretreated with bradykinin receptor B1 (BDKRB1) siRNA and then exposed to bradykinin. Wound-healing (E) and Matrigel-invasion (F) assays were performed, and results were statistically analyzed. Each value represents the mean ± standard deviation (SD), n = 9. Symbols * and ^# indicate that the values significantly (p < 0.05) differed from the control and BDKRB1 siRNA-treated groups, respectively. Representative morphological images are shown.