Table 1.
Studies of IL-6 levels in physical diseases associated with depression.
| Physical Disorders | IL-6 Levels in Patients with Depression | Reference |
|---|---|---|
| Cancer | Higher plasma IL-6 levels in patients with depression. | [60] |
| Cancer | Depression state was positively correlated with IL-6 levels. | [61] |
| Lung cancer | Depression status was positively correlated with IL-6 levels. | [62] |
| Colorectal cancer | Serum IL-6 levels revealed positive associations of depression. | [63] |
| Pancreatic cancer | An association between depression and serum IL-6. | [64] |
| Breast cancer | Depression group had markedly higher plasma IL-6 levels than the other group. | [66] |
| Breast cancer | Plasma IL-6 was significantly correlated with symptoms of depression. | [65] |
| Breast cancer | Plasma IL-6 is strongly associated with depression. | [67] |
| Advanced cancer | Among those whose blood was drawn within 48 h of interview completion, depression and plasma IL-6 were highly correlated. | [68] |
| Ovarian cancer | Greater vegetative depression was related to elevated plasma IL-6 | [69] |
| Terminally ill cancer patients | Neither of the depressive symptoms nor their severity was associated with plasma IL-6 levels. | [71] |
| Cardiovascular risk factors | Elevated serum IL-6 levels are linked to the presence of depression. | [72] |
| Rheumatoid arthritis | No significant differences were found between depression scale and serum IL-6 levels | [73] |
| Rheumatoid arthritis | There was a direct correlation between depression rating and IL-6 levels. | [75] |
| Hemodialysis | Serum IL-6 levels were positively correlated with the values of depression scale. | [78] |
| Hemodialysis | Depressed patients had higher serum IL-6 levels. | [77] |
| Hemodialysis | Depressed patients showed an increase serum IL-6 levels. | [76] |
| Hemodialysis | Serum IL-6 was higher in patients with depressive symptoms. | [79] |
| Hemodialysis | A correlation of IL-6 levels was found with both depression and fatigue in hemodialysis patients. | [80] |
| Hemodialysis | No relationship was found between depression and plasma IL-6 levels. | [81] |
| Continuous ambulatory peritoneal dialysis | In patients without depression, plasma IL-6 levels were significantly lower. | [81] |
| Osteoarthritis | The serum IL-6 levels were associated with depression severity. | [82] |
| Multiple sclerosis | Increase in interleukin-6 levels is related to depressive symptoms. | [83] |
| Interferon-alpha therapy | High circulating IL-6 levels may be risk factors for interferon-alpha induced depression. | [84] |
| Hematopoietic stem cell transplantation | Patients with depression showed significantly higher serum IL-6 levels. | [85] |
| Coronary artery bypass grafting | Acute changes in depressive symptom severity were not associated with IL-6 levels. | [86] |
| Total knee replacement | Plasma IL-6 levels predicted depressive symptoms at three-months following surgery. | [87] |