Figure 2.

Comparison of the EGFR protein expression in primary and metastatic colorectal cancer tissues. (A) Distribution of EGFR expression levels in primary versus metastatic tumor tissues as represented with various H-score ranges. (B) Variations of EGFR-HS (H-score) in colorectal cancer metastases as compared to the corresponding primary tumor (N = 27). Data are expressed as H-score differences of metastatic minus primary tumor at individual case level. (0 = no change, negative value = decrease, + value = increase). (C) Comparison of EGFR H-score of the primary tumors with different metastatic potentials (single metastasis, sm, N = 22) versus multiple-metastasis, (mm N = 66), * p = 0.007. Comparison of metastatic tumors with single metastastasis (sm) versus multiple metastases (mm), ** p = 0.04. Data are expressed as median+/− SD, Mann–Whitney test.