Table 1.
PTMs of OCT-3/4, and E3 ligases and DUBs regulating OCT-3/4.
| References | ||||
|---|---|---|---|---|
| OCT-3/4 | Cancer cells | Cell line | Cervical cancer | [3,56] |
| Testicular germ cell tumor (TGCTs) | [4,5,57,66] | |||
| Drug-resistant cells (prostate cancer) | [5,7,58,59,83] | |||
| Undifferentiated tumor-initiating cells (TICs) | [7,57,79,80,81,82,83,84,85,86,87] | |||
| Colon cancer | [7,61,89] | |||
| Breast cancer | [1,63,89] | |||
| Kinases | Phosphorylation: Serine 347 | [34] | ||
| PTMs | Modified residues of OCT-3/4 | 1. Phosphorylation: Serine 347 | [34] | |
| 2. SUMOylation: Lysine 118 | [46,47] | |||
| 3. O-linked-N-acetylglucosamine (O-GlcNAc): Threonine 228 | [14] | |||
| E3 ligases | WW domain-containing protein 2 (WWP2) | [49,50,51] | ||
| Itchy E3 ubiquitin protein ligase (Itch) | [50,51] | |||
| Carboxy terminus of HSP-70-interacting protein (CHIP) | [1] | |||
| Double PHD fingers 2 (DPF2) | [36] | |||
| Ring finger protein 2 (RNF2) | [73] | |||
| F-box and WD repeat domain containing 8 (FBXW8) | [34] | |||
| DUBs | Ubiquitin specific peptidase 44 (USP44) | [17,54,55] | ||
| Ubiquitin specific peptidase 34 (USP34) | [52] | |||
| Ubiquitin specific peptidase 7 (USP7) | [55] | |||
| 26S proteasome non-ATPase regulatory subunit 14 (PSMD14) | [17] | |||