Table 1.

Host factors involved in HCV entry that have been suggested as antiviral targets. Only host factors for which host-targeting entry inhibitors, e.g., monoclonal antibodies (mAbs) or small molecule inhibitors have at least reached in vivo preclinical development are listed. A comprehensive list of host factors and their role(s) in HCV entry is provided in [17].

Host Factor	HCV Entry Steps	Host-Targeting Agents	References
Scavenger receptor BI (SR-BI)	Attachment, postbinding, cell-to-cell transmission	Anti-SR-BI mAbs ITX5061	[46,47,48,49,50,51,52,53,128,146,147,148]
CD81	Postbinding, endocytosis, signaling, cell-cell transmission	Anti-CD81 mAbs	[37,47,67,78,96,149,150,151,152]
Claudin-1 (CLDN1)	Postbinding, endocytosis, cell-cell transmission	Anti-CLDN1 mAbs	[21,66,69,70,96,143,144,153,154]
Occludin (OCLN)	Postbinding, endocytosis, cell-cell transmission	Anti-OCLN mAbs	[22,89,90,155,156,157,158,159]
Epidermal growth factor receptor (EGFR)	Postbinding, endocytosis, signaling, cell-cell transmission	Anti-EGFR mAbs Erlotinib	[77,79]
Niemann-Pick C1-like 1 (NPC1L1)	Postbinding, fusion, cell-cell transmission	Ezetimide	[95]
5-HT2AR	Endocytosis, fusion	Phenoxybenzamine	[122]