Table 1.
Division of claudins based on the sequence similarity and their chromosomal localization, protein size, and molecular weight.
| Gene | Localization | Protein Size (AA) | Molecular Weight (kDa) |
|---|---|---|---|
| Classic Claudins | |||
| CLDN1 | 3q28 | 211 | 22.74 |
| CLDN2 | Xq22.3 | 230 | 24.55 |
| CLDN3 | 7q11.23 | 220 | 23.32 |
| CLDN4 | 7q11.23 | 209 | 22.08 |
| CLDN5 | 22q11.21 | 218 | 23.15 |
| CLDN6 | 16p13.3 | 220 | 23.29 |
| CLDN7 | 17p13 | 211 | 22.39 |
| CLDN8 | 21q22.11 | 225 | 24.85 |
| CLDN9 | 16p13.3 | 217 | 22.85 |
| CLDN10 | 13q32.1 | 226 | 24.25 |
| CLDN14 | 21q22.3 | 239 | 25.70 |
| CLDN15 | 7q11.22 | 228 | 24.36 |
| CLDN17 | 21q22.11 | 224 | 24.60 |
| CLDN19 | 1p34.2 | 224 | 23.23 |
| Non-Classic Claudins | |||
| CLDN11 | 3q26.2 | 207 | 21.99 |
| CLDN12 | 7q21 | 244 | 27.11 |
| CLDN13* | |||
| CLDN16 | 3q28 | 305 | 33.84 |
| CLDN18 | 3q22.3 | 261 | 27.86 |
| CLDN20 | 6q25 | 219 | 23.52 |
| CLDN21 | 4q35.1 | NI | NI |
| CLDN22 | 4q35.1 | 220 | 24.51 |
| CLDN23 | 8p23.1 | 292 | 31.92 |
| CLDN24 | 4q35.1 | 205 | 22.80 |
* absent in humans and chimpanzees, NI—no information; CLDN—claudin gene; AA—amino acids.