Table 5.
The diagnostic value of circRNAs in digestive system cancers.
| Cancer Type | CircRNA | Dysregulation | Sample | Clinicopathological Factors | AUC | Sensitivity | Specificity | References |
|---|---|---|---|---|---|---|---|---|
| OSCC | Hsa_circ_001242 | Down | Cancer tissue | Tumour size, T stage | 0.784 | 0.725 | 0.775 | [95] |
| Hsa_circ_0001874 | Up | Patients’ saliva | TNM stage, tumour grade | 0.863 | 0.7444 | 0.9024 | [96] | |
| Hsa_circ_0001971 | Up | Patients’ saliva | TNM stage | 0.845 | 0.7556 | 0.878 | [96] | |
| Hsa_circ_0001874 + hsa_circ_0001971 | - | - | - | 0.922 | 0.9268 | 0.7778 | [96] | |
| GC | Hsa_circ_002059 | Down | Cancer tissue | Distal metastasis, TNM stage, gender, age | 0.73 | 0.81 | 0.62 | [98] |
| Hsa_circ_0000190 | Down | Cancer tissue | Tumour diameter, lymphatic metastasis, distal metastasis, TNM stage, CA19-9 | 0.75 | 0.721 | 0.683 | [103] | |
| Patients’ plasma | CEA | 0.6 | 0.414 | 0.875 | ||||
| Cancer tissue + Patients’ plasma | - | 0.775 | 0.712 | 0.75 | ||||
| Hsa_circ_0000745 | Down | Cancer tissue | Tumour differentiation | - | - | - | [100] | |
| Patients’ plasma | TNM stage | 0.683 | 0.855 | 0.45 | ||||
| Patients’ plasma + CEA | - | 0.775 | 0.8 | 0.633 | ||||
| Hsa_circ_0000520 | Down | Cancer tissue | TNM stage | 0.6129 | 0.5357 | 0.8571 | [9] | |
| Patients’ plasma | CEA | 0.8967 | 0.8235 | 0.8444 | ||||
| Hsa_circ_0000181 | Down | Cancer tissue | Tumour diameter, lymphatic metastasis, distal metastasis, CA19-9 | 0.756 | 0.539 | 0.852 | [101] | |
| Patients’ plasma | Differentiation, CEA | 0.582 | 0.99 | 0.206 | ||||
| Hsa_circ_0074362 | Down | Cancer tissue | Lymphatic metastasis, CA19–9 | 0.63 | 0.362 | 0.843 | [102] | |
| CRC | Hsa_circ_001988 | Down | Cancer tissue | Differentiation, perineural invasion | 0.788 | 0.68 | 0.73 | [109] |
| Hsa_circ_0003906 | Down | Cancer tissue | Lymphatic metastasis, differentiation | 0.818 | 0.803 | 0.725 | [45] | |
| Hsa_circ_0000567 | Down | Cancer tissue | Tumour size, lymph metastasis, distal metastasis, TNM stage | 0.8653 | 0.8333 | 0.7647 | [55] | |
| Hsa_circ_0026782 | Down | Cancer tissue | Tumour size, lymph metastasis, distant metastasis, TNM stage | 0.8791 | 0.9275 | 0.6667 | [52] | |
| Hsa_circ_0000069 | Up | Cancer tissue | TNM stage, age | - | - | - | [48] | |
| HCC | Hsa_circ_0003570 | Down | Cancer tissue | Tumour diameter, differentiation, microvascular invasion, BCLC stages, TNM stages, serum AFP | 0.7 | 0.449 | 0.868 | [110] |
| Hsa_circ_0001445 | Down | Cancer tissue | The number of tumour foci | - | - | - | [71] | |
| Patients’ plasma | Serum AFP | 0.862 | 0.712 | 0.942 | ||||
| Hsa_circ_104075 | Up | Cancer tissue | - | - | - | - | [61] | |
| Patients’ serum | - | 0.973 | 0.96 | 0.983 | ||||
| Hsa_circ_0016788 | Up | Cancer tissue | - | 0.851 | - | - | [67] | |
| PC | Circ-LDLRAD3 | Up | Cancer tissue | Venous invasion, lymphatic invasion, clinical stage, T classification | 0.67 | 0.5738 | 0.7049 | [97] |
| Patients’ plasma | CA19-9, N classification, venous invasion, lymphatic invasion, clinical stage, metastasis | |||||||
| Circ-LDLRAD3 + CA19-9 | - | - | - | 0.87 | 0.8033 | 0.9355 | [97] |