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. 2020 Mar 14;12(3):690. doi: 10.3390/cancers12030690

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Single-cell RNA-seq analysis of 4T1 tumor and tumoroid cultures. (A) Merged uniform manifold approximation and projection (UMAP) of identified cells from a syngeneic tumor (in vivo) and 5-day ex vivo tumoroid (EV3D) cultures. (B) Cell type abundance from original tumor and tumoroids. (C) Abundance of proliferating cancer cells (Epcam⁺/Mki67⁺) in tumor/tumoroid. (D) Abundance of inflammatory macrophages (Ptprc⁺/CD14⁺/Il1b⁺) in tumor/tumoroid. (E) Abundance of myofibroblast (Thy1⁺/Dcn⁺/Acta2) in tumor/tumoroid.