Table 2.
Univariate analysis (Cox regression) of circulating miR-483-5p and clinicopathological parameters in relation to overall survival (OS) and recurrence-free survival (RFS).
| Variable | OS | RFS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p Value | HR | 95% CI | p Value | |
| Age | 1.02 | 0.97–1.07 | 0.373 | 1.01 | 0.97–1.05 | 0.601 |
| Sex | 0.90 | 0.26–3.08 | 0.862 | 0.87 | 0.28–2.68 | 0.817 |
| Tumor size | 1.02 | 0.92–1.13 | 0.684 | 1.05 | 0.96–1.15 | 0.274 |
| Ki67 > 10% | 0.45 | 0.12–1.69 | 0.239 | 0.38 | 0.11–1.26 | 0.083 |
| ENSAT stage I–II vs. III | 0.70 | 0.21–2.33 | 0.566 | 0.54 | 0.18–1.61 | 0.269 |
| miR-483-5p cut-off | 2.79 | 0.85–9.19 | 0.090 | 4.84 | 1.53–15.3 | 0.007 |
Univariate analysis includes quantitative variables (age; tumor size), qualitative variables (sex; ENSAT stage I, II vs. III), and dichotomized variables (Ki67 > 10% as the reference category; miR-483-5p < 752,898 copy number/mL as the reference category). HR: hazard ratio; 95% CI: 95% confidence interval. Bold numbers indicate a significant difference.