Table 1.
Clinical, histopathological, serological and gene expression features of children with ACC in this study.
| Patient | Gender | TP53 | Age at Diagnosis (Years) | Staging | Clinical Manifestations | Weight (g) | Histopathology | Treatment | Recurrence | Outcome | DFS (Months) | FATE1 H-score | Anti-FATE1 Abs IF+ | Anti-FATE1 Abs ELISA+ | Anti-FATE1 Abs WB+ | FATE1 mRNA Expression Data |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F | R337H | 10 | 1 | V | 110 | ACC | S + C | Yes | DD | 17 | 1 | + | - | + | NA |
| 2 | M | R337H | 7 | 2 | V | 238 | ACC | S + C | No | Alive | 65 | 0.1 | + | - | + | NA |
| 3 | F | R337H | 7 | 4 | V | 342 | ACC | S + C | Yes | DD | 18 | 1 | + | + | + | NA |
| 4 | F | R337H | 1 | 1 | V | 16 | ACC | S + C | No | Alive | 38 | 3 | - | - | + | NA |
| 5 | M | R337H | 1 | 2 | CS + HBP | 126 | ACC | S | No | Alive | 43 | 0.5 | + | - | + | NA |
| 6 | F | R337H | 5 | 2 | V | 318 | ACC | S + C | No | Alive | 48 | 1 | - | - | + | NA |
| 7 | M | R337H | 0 | 1 | NF | 50 | ACC | S | No | Alive | 41 | 0.2 | + | - | + | NA |
| 8 | F | R337H | 1 | 1 | V + CS | 62 | ACC | S | No | Alive | 38 | 1.5 | - | - | + | NA |
| 9 | F | R337H | 1 | 2 | V | 253 | ACC | S | No | Alive | 19 | 0.1 | + | - | + | NA |
| 10 | M | R337H | 1 | 2 | V + CS | 105 | ACC | S | No | Alive | 38 | 1 | - | - | + | NA |
| 11 | F | R337H | 7 | 4 | V | 184 | ACC | S + C | No | DD | 16 | NA | - | + | + | NA |
| 12 | F | R337H | 1 | 3 | V | 32 | ACC | S + C | Yes | DD | 25 | NA | - | - | + | NA |
| 13 | M | R337H | 1 | 1 | V + CS | 12 | ACC | S | No | Alive | 84 | 3 | NA | NA | NA | NA |
| 14 | F | R337H | 1 | 2 | V + CS | 212 | ACC | S | No | Alive | 83 | 0.1 | NA | NA | NA | NA |
| 15 | F | R337H | 3 | 3 | V | 125 | ACC | S + C | No | DD | 5 | 1 | NA | NA | NA | NA |
| 16 | M | R337H | 10 | 1 | V + CS | NA | ACC | S + C | No | Alive | 23 | 0.2 | NA | NA | NA | NA |
| 17 | F | R337H | 2 | 2 | V | 275 | ACC | S | No | Alive | 38 | 3 | NA | NA | NA | NA |
| 18 | M | R337H | 3 | 2 | V | 300 | ACC | S | No | Alive | 151 | 2 | NA | NA | NA | NA |
| 19 | F | WT | 9 | 1 | V + CS | 15 | ACC | S | No | Alive | 86 | 1 | NA | NA | NA | NA |
| 20 | M | R337H | 2 | 4 | V + CS | 80 | ACC | S + C | No | Alive | 154 | 1 | NA | NA | NA | NA |
| 21 | F | R337H | 2 | 2 | V | 127 | ACC | S | No | Alive | 106 | 0.1 | NA | NA | NA | NA |
| 22 | F | R337H | 2 | 1 | V | 77 | ACC | S | No | Alive | 38 | 1 | NA | NA | NA | NA |
| 23 | F | WT | 2 | 1 | V + CS | 82 | ACC | S | No | Alive | 84 | 0.3 | NA | NA | NA | NA |
| 24 | F | R337H | 1 | 1 | V + CS | 33 | ACC | S | No | Alive | 48 | 1.5 | NA | NA | NA | NA |
| 25 | F | R337H | 2 | 4 | V + CS | 392 | ACC | S + C | No | DD | 13 | 1.5 | NA | NA | NA | NA |
| 26 | M | R337H | 1 | 2 | NF | 300 | ACC | S | No | Alive | 220 | 0.2 | NA | NA | NA | NA |
| 27 | M | R337H | 15 | 4 | AbM | 3150 | ACC | S + C | No | Alive | 48 | 0 | NA | NA | NA | NA |
| 28 | F | WT | 1 | 3 | V + CS | 98 | ACC | S + C | No | Alive | 60 | 0.1 | NA | NA | NA | NA |
| 29 | F | R337H | 8 | 3 | V | 300 | ACC | S + C | No | Alive | 125 | 0.2 | NA | NA | NA | NA |
| 30 | F | WT | 1 | 2 | C | 120 | ACC | S | No | Alive | 51 | NA | NA | NA | NA | Yes |
| 31 | M | WT | 3 | 3 | V + CS | 144 | ACC | S + C | No | Alive | 84 | NA | NA | NA | NA | Yes |
| 32 | F | WT | 1 | 4 | V + CS | 80 | ACC | S + C | No | Alive | 40 | NA | NA | NA | NA | Yes |
| 33 | F | WT | 17 | 4 | V | 1000 | ACC | S + C | Yes | DD | 18 | NA | NA | NA | NA | Yes |
| 34 | M | WT | 15 | 4 | V + CS | 579 | ACC | S + C | Yes | DD | 10 | NA | NA | NA | NA | Yes |
| 35 | F | WT | 4 | 1 | V | 69 | ACC | S | No | Alive | 18 | NA | NA | NA | NA | Yes |
| 36 | M | WT | 12 | 4 | C | NA | ACC | C | Yes | DD | 6 | NA | NA | NA | NA | Yes |
| 37 | F | WT | 2 | 2 | V | 190 | ACC | S | No | Alive | 52 | NA | NA | NA | NA | Yes |
| 38 | F | R337H | 4 | 3 | V | 260 | ACC | S + C | No | Alive | 61 | NA | NA | NA | NA | Yes |
| 39 | F | R337H | 3 | 1 | V | 6 | ACC | S | No | Alive | 62 | NA | NA | NA | NA | Yes |
| 40 | F | R337H | 1 | 3 | V + CS | 86 | ACC | S + C | No | Alive | 48 | NA | NA | NA | NA | Yes |
| 41 | F | R337H | 3 | 1 | V | 30 | ACC | S | No | Alive | 51 | NA | NA | NA | NA | Yes |
| 42 | F | R337H | 1 | 3 | V | 68 | ACC | S + C | No | Alive | 55 | NA | NA | NA | NA | Yes |
| 43 | F | R337H | 1 | 2 | V | 142 | ACC | S | No | Alive | 52 | NA | NA | NA | NA | Yes |
| 44 | F | R337H | 3 | 1 | V | 12 | ACC | S | No | Alive | 65 | NA | NA | NA | NA | Yes |
| 45 | F | R337H | 1 | 1 | V | 80 | ACC | S | No | Alive | 22 | NA | NA | NA | NA | Yes |
| 46 | F | R337H | 8 | 1 | V | 22 | ACC | S | No | Alive | 21 | NA | NA | NA | NA | Yes |
| 47 | M | R337H | 16 | 4 | NF | NA | ACC | C | Yes | DD | 7 | NA | NA | NA | NA | Yes |
| 48 | F | splice | 1 | 3 | V | 117 | ACC | S + C | No | Alive | 69 | NA | NA | NA | NA | Yes |
| 49 | M | splice | 6 | 2 | V | 810 | ACC | S | Yes | DD | 4 | NA | NA | NA | NA | Yes |
| 50 | M | DBD | 1 | 1 | V | 10 | ACC | S | No | Alive | 59 | NA | NA | NA | NA | Yes |
| 51 | M | DBD | 1 | 1 | V | 56 | ACC | S | No | Alive | 52 | NA | NA | NA | NA | Yes |
| 52 | F | DBD | 3 | 3 | C | 466 | ACC | S + C | Yes | Alive | 18 | NA | NA | NA | NA | Yes |
| 53 | M | DBD | 13 | 4 | NF | 579 | ACC | S + C | Yes | DD | 2 | NA | NA | NA | NA | Yes |
| 54 | F | DBD | 4 | 2 | NF | 137 | ACC | S | Yes | DD | 56 | NA | NA | NA | NA | Yes |
| 55 | M | DBD | 10 | 3 | NF | 627 | ACC | S + C | Yes | Alive | 14 | NA | NA | NA | NA | Yes |
| 56 | M | DBD | 5 | 3 | NF | 595 | ACC | S + C | Yes | Alive | 27 | NA | NA | NA | NA | Yes |
| 57 | F | DBD | 5 | 2 | V | 192 | ACC | S | No | Alive | 25 | NA | NA | NA | NA | Yes |
Clinical manifestations: V, virilizing tumor; CS, Cushing’s syndrome; HBP, hypertension; NF, non-functioning; AbM, abdominal mass. Treatment: S, surgery; C, chemotherapy. Outcome: DD, dead of disease. DFS: disease-free survival. NA: not available.