Table 4.
Clinical, histopathological and serological features of adults with ACT in this study. For patients 29 to 34, serum samples labelled with a were taken before surgery, samples labelled with b after surgery.
| Patient | Gender | Clinical Manifestations | Age at Diagnosis (Years) | Histopathology | ENSAT Stage | Surgical Resection | M | Recurrence | Outcome | DFS (Months) | FATE1 Abs IF+ | FATE1 Abs ELISA+ | FATE1 Abs WB+ | FATE1 H-score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F | Unkn | 51 | ACC | 3 | Yes | Yes | Yes | DD | 3 | - | + | + | NA |
| 2 | M | C, Andro | 18 | ACC | 3 | Yes | Yes | Yes | DD | 9 | - | - | + | NA |
| 3 | F | C, Andro | 45 | ACC | 2 | Yes | Yes | Yes | Alive | 96 | + | + | + | NA |
| 4 | M | Andro, Estro | 69 | ACC | 2 | Yes | No | No | DOC | 41 | - | + | + | NA |
| 5 | F | C, Aldo | 46 | ACC | 2 | Yes | Yes | Yes | DD | 24 | + | + | + | NA |
| 6 | F | C, Andro | 42 | ACC | 2 | Yes | Yes | No | Alive | 104 | - | - | + | NA |
| 7 | M | Unkn | 42 | ACC | 2 | Yes | Yes | Yes | DD | 16 | + | + | + | NA |
| 8 | M | Unkn | 52 | ACC | 3 | Yes | Yes | No | Alive | 98 | + | + | + | NA |
| 9 | F | C, Andro | 58 | ACC | 2 | Yes | Yes | Yes | DD | 8 | - | - | + | NA |
| 10 | F | No | 38 | ACC | 1 | Yes | No | No | Alive | 36 | - | - | + | NA |
| 11 | F | No | 47 | ACC | 3 | Yes | Yes | No | Alive | 30 | - | - | + | NA |
| 12 | F | C | 49 | ACC | 2 | Yes | Yes | Yes | Alive | 36 | - | + | + | NA |
| 13 | M | Andro | 60 | ACC | 2 | Yes | No | Yes | DD | 20 | + | + | + | NA |
| 14 | F | C, Andro | 44 | ACC | 1 | Yes | Yes | Yes | Alive | 69 | + | + | + | NA |
| 15 | F | C | 40 | ACC | 2 | Yes | Yes | Yes | DD | 11 | - | - | + | NA |
| 16 | M | No | 62 | ACC | 3 | Yes | Yes | No | Alive | 27 | - | + | + | NA |
| 17 | F | No | 77 | ACC | 2 | Yes | Yes | No | Alive | 92 | + | + | + | NA |
| 18 | F | Unkn | 70 | ACC | 2 | Yes | Yes | No | Alive | 80 | + | - | + | NA |
| 19 | F | C, Andro | 68 | ACC | 1 | Yes | No | Yes | Alive | 98 | - | + | + | NA |
| 20 | F | Unkn | 46 | ACC | 3 | Yes | Yes | Yes | DD | 3 | - | - | + | NA |
| 21 | F | Unkn | 42 | ACC | 3 | Yes | Yes | Yes | Alive | 29 | - | + | + | NA |
| 22 | F | Unkn | 78 | ACC | 3 | Yes | Yes | Yes | DD | 3 | - | + | + | NA |
| 23 | F | Unkn | 52 | ACC | 2 | Yes | Yes | No | Alive | 65 | - | + | + | NA |
| 24 | F | No | 70 | ACC | 3 | Yes | Yes | No | Alive | 62 | - | - | + | NA |
| 25 | F | Unkn | 53 | ACC | 2 | Yes | Yes | No | Alive | 35 | - | + | + | NA |
| 26 | F | No | 49 | ACC | 2 | Yes | Yes | Yes | Alive | 20 | - | - | + | NA |
| 27 | F | No | 30 | ACC | 2 | Yes | Yes | No | Alive | 4 | + | + | + | NA |
| 28 | M | C, Estro | 21 | ACC | 2 | Yes | Yes | No | Alive | 66 | - | - | + | NA |
| 29a | M | C | 64 | ACC | 2 | Yes | Yes | Yes | DD | 48 | + | + | + | 0.3 |
| 29b | + | + | + | |||||||||||
| 30a | M | No | 49 | ACC | 1 | Yes | No | No | Alive | 78 | - | + | + | NA |
| 30b | - | + | + | |||||||||||
| 31a | M | C | 47 | ACC | 3 | Yes | Yes | No | Alive | 70 | - | + | + | 1.5 |
| 31b | - | + | + | |||||||||||
| 32a | F | Aldo | 51 | ACC | 3 | Yes | Yes | No | Alive | 58 | - | + | + | 0 |
| 32b | - | + | + | |||||||||||
| 33a | M | C | 61 | ACC | 1 | Yes | No | No | Alive | 86 | - | + | + | 3 |
| 33b | + | + | + | |||||||||||
| 34a | F | C, Andro | 38 | ACC | 2 | Yes | No | No | Alive | 74 | + | + | + | 1.5 |
| 34b | - | + | + | |||||||||||
| 35 | M | C | 41 | ACC | 4 | No | Yes | Yes | DD | 5 | + | - | + | NA |
| 36 | F | No | 39 | ACC | 4 | No | Yes | Yes | Alive | 9 | - | - | + | NA |
| 37 | F | C | 60 | ACC | 4 | No | Yes | Yes | DD | 0 | - | - | + | NA |
| 38 | F | C | 57 | ACC | 4 | No | Yes | Yes | DD | 42 | - | + | + | NA |
| 39 | M | No | 79 | ACC | 4 | No | Yes | Yes | Alive | 0 | - | - | + | NA |
| 40 | F | No | 59 | ACC | 2 | Yes | Yes | No | Alive | 19 | + | + | + | NA |
| 41 | F | No | 60 | ACC | 4 | No | Yes | Yes | DD | 0 | + | + | + | NA |
| 42 | F | C | 43 | ACC | 4 | No | Yes | Yes | DD | 0 | - | - | + | NA |
| 43 | M | No | 53 | ACC | 4 | No | Yes | Yes | Alive | 0 | - | + | + | NA |
| 44 | F | C | 47 | ACC | 4 | No | Yes | Yes | DD | 0 | - | + | + | NA |
| 45 | F | C | 36 | ACC | 4 | No | Yes | Yes | DD | 0 | + | + | + | NA |
| 46 | F | No | 59 | ACC | 2 | Yes | Yes | No | Alive | 68 | - | + | + | NA |
| 47 | M | No | 58 | ACA | NA | No | NA | NA | Alive | NA | + | + | + | NA |
| 48 | M | Aldo | 67 | ACA | NA | No | NA | NA | Alive | NA | + | + | + | NA |
| 49 | F | C | 46 | ACA | NA | No | NA | NA | Alive | NA | - | - | + | NA |
| 50 | F | C | 35 | ACA | NA | No | NA | NA | Alive | NA | - | + | + | NA |
| 51 | F | No | 70 | ACA | NA | No | NA | NA | Alive | NA | - | + | + | NA |
| 52 | M | No | 32 | ACA | NA | No | NA | NA | Alive | NA | - | + | + | NA |
| 53 | F | C | 48 | ACA | NA | No | NA | NA | Alive | NA | - | + | + | NA |
| 54 | F | C | 34 | ACA | NA | No | NA | NA | Alive | NA | + | - | + | NA |
| 55 | F | C | 58 | ACA | NA | No | NA | NA | Alive | NA | - | + | + | NA |
| 56 | M | No | 54 | ACA | NA | No | NA | NA | Alive | NA | - | + | + | NA |
Clinical manifestations: Unkn, unknown; C, cortisol-secreting; Andro, androgen-secreting; Estro, estrogen-secreting; Aldo, aldosterone-secreting. Histopathology: ACC, adrenocortical carcinoma; ACA, adrenocortical adenoma. Outcome: DD, dead of disease. DFS: disease-free survival. NA: not available.