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. 2020 Mar 23;12(3):758. doi: 10.3390/cancers12030758

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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MeCP2 is overexpressed in metastatic colorectal cancer (CRC). (A) MeCP2 mRNA is upregulated in CRC tissues compared to normal tissues in the Cancer Genome Atlas (TCGA) cohort (left), and the Oncomine (Gaedcke and Hong) cohorts. (B) MeCP2 protein expression is higher in CRC tissues compared to adjacent normal tissues, as determined by Western blot. (C) Correlation between MeCP2 expression and survival in TCGA database for CRC, analyzed with the Gene Expression Profiling Interactive Analysis (GEPIA) online analysis tool (Kaplan-–Meier analysis of Overall Survival time). HR, hazard ratio. (D) MECP2 mRNA expression is higher in M1 stage CRC patients compared to M0 stage CRC patients. (E) MeCP2 immunohistochemistry (IHC) staining scores in paired adjacent normal, CRC tumor tissues, and liver metastasis tissues (n = 15).