Figure 3.

Molecular characterization of MITF/PTEN groups. (A) Mutational pattern of representative genes of the MAPK and PI3K pathways in MITF/PTEN groups. In MITF^low/PTEN^neg, two harbored PTEN mutation, three cases had PIK3CA mutation, and one had PIK3R1 mutation. In the MITF^high/PTEN^neg group, ten had PTEN mutation and one had PIK3CA mutation. The two other group had one PTEN mutated case each. (B) Mutational load across MITF/PTEN grouping using the number of mutations across 1500 cancer genes. p > 0.5, Kruskal–Wallis analysis. (C) Kaplan–Meier survival analysis using log-rank tests of MITF and PTEN markers combined. Survival data were missing for two cases in both MITF^low/PTEN^neg and MITF^high/PTEN^neg groups and five cases in the MITF^high/PTEN^pos group.