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. 2020 Mar 21;12(3):742. doi: 10.3390/cancers12030742

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Transcriptional analysis of MITF^low/PTEN^neg melanoma tumors. (A) SAM analysis identified genes (n = 276) characteristic of MITF^low/PTEN^neg melanoma tumors. (B) Bar plot showing results from the gene ontology analysis using the 276 genes differentiating MITF^low/PTEN^neg melanoma tumors from other melanomas. Notably, there are two cell adhesion molecule gene ontology terms. Genes downregulated (blue) include immune adhesion molecules, while upregulated genes include classical adhesion molecules such as N-cadherin. (C) Boxplots of the CTNNB1 (beta-catenin) and FZD1 gene expression value across the MITF/PTEN groups. CTNNB1 shows no significant difference (p = 0.24), while FZD1 expression shows a significant difference (p < 0.0001).