Table 1.
Clinical features of the 169 melanoma cases in correlation with PTEN status. p-values from Fisher’s exact test, not adjusted for multiple testing.
| Feature | Entire Cohort (n = 169) | PTEN+ (n = 69) | PTEN− (n = 100) | p-Value |
|---|---|---|---|---|
| Gender n (%) | 1 | |||
| Male | 98 (58) | 39 (57) | 59 (59) | |
| Female | 69 (41) | 28 (41) | 41 (41) | |
| NA | 2 (1) | 2 (3) | - | |
| Age at diagnosis median (range) | 65 (22–91) | 65 (22–91) | 65 (30–88) | 0.54 |
| Stage | 0.003 | |||
| II | 18 (11) | 13 (19) | 5 (5) | |
| III | 99 (59) | 41 (59) | 58 (58) | |
| IV | 50 (29) | 13 (19) | 37 (37) | |
| NA | 2 (1) | 2 (3) | 0 | |
| Lesion type | 0.004 | |||
| Lymph node | 108 | 36 | 72 | |
| Subcutaneous | 35 | 16 | 19 | |
| Visceral | 10 | 4 | 6 | |
| Primary tumor | 14 | 11 | 3 | |
| NA | 2 | 2 | - | |
| Histological subtype | 0.5 | |||
| Unknown primary n (%) | 26 (15) | 9 (13) | 17 (17) | |
| SSM | 35 (21) | 11 (16) | 24 (24) | |
| NM | 57 (34) | 24 (35) | 33 (33) | |
| Other | 14 (8) | 5 (6) | 9 (9) | |
| NA | 37 (22) | 20 (29) | 17 (17) |
SSM, superficial spreading melanoma; NM, nodular melanoma; NA, not available.