Table 1.
Main clinical characteristics of the 56 patients and univariate p-values (log-rank test) for time to relapse (TTR) and overall survival (OS).
| Characteristics | Subtypes | N (%) | TTR* | OS* |
|---|---|---|---|---|
| Sex | Male | 38 (67.9) | ||
| Female | 18 (32.1) | 0.802 | 0.953 | |
| Age, years | Mean age (range) | 63 (32–80) | ||
| ≤65 | 32 (57.1) | |||
| >65 | 24 (42.9) | 0.845 | 0.177 | |
| Stage | I | 29 (51.8) | ||
| II | 21 (37.5) | |||
| III | 6 (10.7) | 0.016 | 0.05 | |
| Histological subtype | Adenocarcinoma | 33 (58.9) | ||
| Squamous cell carcinoma | 14 (25.0) | |||
| Other | 9 (17) | 0.715 | 0.989 | |
| ECOG PS | 0 | 25 (44.6) | ||
| 1 | 31 (55.4) | 0.989 | 0.175 | |
| Adjuvant treatment | Yes | 20 (35.7) | 0.036 | 0.233 |
| Relapse | Yes | 17 (30.4) | ||
| Type of surgery | Lobectomy/bilobectomy | 44 (78.6) | ||
| Pneumonectomy | 6 (10.7) | |||
| Segmentectomy | 5 (8.9) | |||
| Atypical resection Anatomical resection |
1 (1.8) 4 (7.6) |
0.438 0.482 |
0.543 0.407 |
|
| Smoking history | Current smoker | 30 (53.5) | ||
| Former smoker | 23 (41.1) | |||
| Never smoker | 3 (5.4) | 0.901 | 0.197 | |
| Molecular features | KRAS mutation | 7/48 (14.9) | 0.288 | 0.449 |
| TP53 mutation | 21/48 (43.8) | 0.009 | 0.015 |
ECOG PS: Eastern Cooperative Oncology Group Performance Status. * Significant values are shown in bold.