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. 2020 Mar 23;12(3):755. doi: 10.3390/cancers12030755

Figure 1.

Figure 1

Identified germline mitochondrial mutations in early-stage lung adenocarcinoma patients. (a) Spectrum of germline mutations in 61 patients. Each row corresponds to a mitochondrial gene or region, and the color intensity indicates the number of mutations. (b) Germline mutation frequency (per kbp) in mitochondrial genomic regions with respect to haplogroup, age, and EGFR-activating mutation status. Abbreviations: EGFR+: patients harboring EGFR-activating mutations; EGFR−: patients without EGFR-activating mutations.