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. 2020 Mar 23;12(3):755. doi: 10.3390/cancers12030755

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Nucleotide substitution profiles of mitochondrial mutations. (a) Nucleotide substitution profiles of germline mitochondrial mutations among different cancers. (b) Nucleotide substitution profiles of somatic mitochondrial mutations among different cancers. Cancer types marked with * provided the somatic mutation in the coding region only. Abbreviations: ACC: adenoid cystic carcinoma; ALL: acute lymphocytic leukemia; ALM: acute myeloid leukemia; CHOAL: cholangiocarcinoma; COAD: colon adenocarcinoma; Kidney Chromo.: kidney chromophobe; LHC: liver hepatocellular carcinoma; MDS: myelodysplastic syndromes; MPD: myeloproliferative disorders; OV: ovarian serous cystadenocarcinoma; KPCC: kidney renal papillary cell carcinoma; READ: rectum adenocarcinoma; LUAD_TCGA: lung adenocarcinoma TCGA; LUSC_KR: lung squamous cell carcinoma Korea; LUAD_TW: lung adenocarcinoma Taiwan.