Table 1.
Various five-year outcome parameters of early stage glottic laryngeal cancer (T1-2N0) according to T stage.
| Stage | Local Control | Disease-Specific Survival | Disease-Free Survival | Overall Survival | Voice | Laryngeal Preservation | Comment |
|---|---|---|---|---|---|---|---|
| % | |||||||
| T1a | RT: 93 TOLS: 81 [14] | RT: 96 TOLS: 100 [14] | RT: 78 TOLS: 69 [14,15] | RT: 86–89 TOLS: 86–87 [14] | Significantly better VHI, GRBAS, jitter, shimmer, noise-harmonic rate and maximum phonation time after RT (1) [14,16] | RT: 77–93 TOLS: 69–100 [14] | No significant difference except for (1) |
| T1b | RT: 86 TOLS: 95 in 2 years * [17] | RT: 86 TOLS: 89 in 2 years * [17] | RT: 95 TOLS: 94 in 2 years * [17] | Significantly better VHI and less voice deficiency after RT (1) [14] | RT: 86 TOLS: 100 in 2 years * [17] | No significant difference except for (1) | |
| T1a-b mixed | RT: 87-94 TOLS: 75–91 (1) [5,14,18] | RT: 96–97 TOLS: 100 [5,14] | RT: 87% TOLS: 75% (1) [5] | RT: 79–89 TOLS: 86–91 [5,14,18] | Significantly better understandability and VHI scores after RT (2) [14,19] No difference (3) [18] Varied (4) [20] | RT:93–94 TOLS: 100 [14,18] |
No significant difference except for (1): one study [5] showed better LC and DFS after RT. (2): Better understandability and VHI scores after RT (3): One study [18] showed no difference. (4): One study [20] showed worse GRBAS if cordectomy > type II |
| T2 | RT: 76 TOLS: 88 in 3 years * [21] | RT: 71 TOLS: 88 in 3 years * [21] | RT: 94 TOLS: 100 in 3 years * [21] | No significant difference despite selection bias | |||
| T1-2 mixed | RT: 86 TOLS: 75 [14] | RT: 94 TOLS: 99 [14] | RT: 72 TOLS: 90 [14] | Significantly better VHI and understandability after RT(1) [14,19] | RT: 76-83 TOLS: 87-93(2) [14,19] | No significant difference except for (1) and (2): One study [14] showing better (93% vs. 83%) laryngeal preservation after TOLS, whereas RT was more often offered for advanced stages. |
|
*: No study with five-year outcome found that compared treatment modalities on patients exclusively treated in and after 1999; DFS: disease-free survival; GRBAS: grade (G), roughness (R), breathiness (B), asthenia (A), and strain (S); LC: local control; RT: radiotherapy; TOLS: transoral laser surgery; VHI: voice handicap index.