Table 1.

Chemotherapy protocols tested in the study, and corresponding equivalent plasma concentration (EPC) calculated as EPC = clinical dose x BSA / V, as BSA is the reference value of the Body Surface Area (1.8 m²) and V is the reference value of the blood volume (5.4 L). IC50, LD25 and relative ratio EPC/IC50, EPC/LD25.

Chemotherapy Protocol	Drugs Combination	Clinical Dose (mg/mq)	EPC (mg/mL)	IC50 (mg/mL)	LD25 (mg/mL)	EPC/IC50	EPC/LD25
Gemcitabine	Gemcitabine	1000	0.34	0.1	0.076	3.35	4.41
GEMOX	Gemcitabine	1000	0.34	0.23	0.16	1.50	2.13
	Oxaliplatin	100	0.034	0.023	0.016
GEM/nab-P	Gemcitabine	1000	0.34	0.11	0.089	3.03	3.77
	nab-Paclitaxel	125	0.04	0.014	0.011
GEMCIS	Gemcitabine	1000	0.34	0.19	0.1	1.75	3.35
	Cisplatin	25	0.01	0.0048	0.0025
5-FU	5-Fluorouracil	3200	1.08	6.66	7.56	0.16	0.14
FOLFOX	5-Fluorouracil	2800	0.94	6.55	6.29	0.14	0.15
	Lederfolin	200	0.07	0.47	0.45
	Oxaliplatin	85	0.03	0.2	0.19
FOLFIRI	5-Fluorouracil	2800	0.94	0.15	0.19	6.21	5.03
	Lederfolin	200	0.07	0.011	0.013
	Irinotecan	180	0.06	0.01	0.012
FOLFOXIRI	5-Fluorouracil	3200	1.08	0.09	0.22	11.99	4.83
	Lederfolin	200	0.07	0.0056	0.014
	Oxaliplatin	85	0.03	0.0024	0.0059
	Irinotecan	165	0.06	0.0046	0.012
FLOT	5-Fluorouracil	2600	0.88	0.28	0.27	3.08	3.23
	Lederfolin	200	0.07	0.022	0.02
	Oxaliplatin	85	0.03	0.0093	0.0089
	Docetaxel	50	0.02	0.0055	0.0052
ECF	5-Fluorouracil	2800	0.94	3.29	2.54	0.29	0.37
	Cisplatin	60	0.02	0.07	0.054
	Epirubicin	50	0.02	0.059	0.045