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ATRTs are p53-proficient tumors. (a) IHC staining for p53 in primary and recurrent tumors. High expression of p53 in ATRTs. (b) WES of 16 patients with ATRT indicated no case of TP53 mutation. (c) High expression of TP53 mRNA in ATRTs (n = 24) compared with normal brain tissues (n = 4). **** p < 0.0001, Mann–Whitney U test. Scale bar, 50 µm.
